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- Title
Mucosal immunology: It starts with a NOD.
- Authors
Bird, Lucy
- Abstract
The article offers information on the latest research on formation of isolated lymphoid follicles (ILFs). It investigates the process of molecular mechanism for ILFs genesis in mice, using the comparative analysis in which mice which are deficient of nucleotide-binding oligomerization domain protein 1 (NODI) are compared with the wild type. The results proved that pattern-recognition receptors are involved in the process, and only NODI-deficient mice showed impairment in the formation of ILFs.
- Subjects
COMPARATIVE studies; NUCLEOTIDES; CELL receptors; LYMPHOID tissue; MICE physiology
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 12, p909
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2461