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- Title
Association between TyG-WC and risk of coronary heart disease in middle-aged and elderly population: a prospective cohort study with 10-year follow-up.
- Authors
WANG Yu; MIAO Ying; LIN Qiang; TIAN Mao; CHEN Zhuang; WAN Qin
- Abstract
Objective To investigate the association between triglyceride glucose index (TyG) combined with waist circumference (WC) and the risk of new-onset coronary heart disease (CHD) in the middle-aged and elderly people in 10 years of non-interventional follow-up in Luzhou area. Methods A total of 8 647 eligible individuals participated in epidemiological survey in Luzhou area were selected. The subjects were divided into different groups according to the quartiles of the TyG-WC and followed for ten years. The correlation between different TyG-WC quartile group and 10-year new CHD in middle-aged and elderly population was analyzed by using univariate analysis and Cox regression analysis. Results Of the 8 647 participants in the study, 484 had new CHD, accounting for 5.5%. The comparison of the number of newly diagnosed CHD subjects grouped by TyG-WC quartiles indicated the 4th quartile group > the 3rd quartile group > the 2nd quartile group > the 1st quartile group, showing statistical significance (P < 0.001). Cox regression analysis showed that without adjusting for any variables, the risk of new CHD in 10 years increased with the increase of TyG-WC quartile group, and the differences between the second, third and fourth quartile array and the first quartile array were statistically significant (P < 0.05). After adjusting for age and sex and further adjusting for the influence of various influencing factors, the risk of new CHD in 10 years increased with the increase of TyG-WC quartile group. The difference between the third and fourth quartile array and the first quartile array was statistically significant (P < 0.05). Conclusion TyG-WC is a risk factor for new-onset CHD in the middle-aged and elderly population in Luzhou area in 10 years of non-interventional follow-up, and TyG-WC may be a predictor of the risk of CHD in the middle-aged and elderly population.
- Subjects
OLDER people; CORONARY disease; MIDDLE-aged persons; COHORT analysis; LONGITUDINAL method
- Publication
Journal of Practical Medicine / Shiyong Yixue Zazhi, 2024, Vol 40, Issue 12, p1731
- ISSN
1006-5725
- Publication type
Article
- DOI
10.3969/j.issn.1006-5725.2024.12.020