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- Title
Lactononadecapeptide (NIPPLTQTPVWPPFLQPE) Improves Amyloid β Peptide-induced Memory Impairment in Mice.
- Authors
Fumiya Nakamura; Kazuhito Ohsawa; Koki Sato; Yasunori Nakamura
- Abstract
Alzheimer's disease is the most common form of dementia and is characterized by neuritic plaques in the brain that contain amyloid β (Aβ) peptide. Deposition of Aβ plaques affects synaptic function and is associated with learning and memory impairment. The aim of this study was to evaluate the effect of lactononadecapeptide (LNDP; NIPPLTQTPVWPPFLQPE), derived from β-casein, on an Aβ25-35-induced Alzheimer's disease model and to investigate the mechanism of action of LNDP. We investigated the effect of LNDP on memory impairment induced by an intracerebroventricular injection of Aβ25-35 and neurotrophic gene expression in ddY mice. LNDP (0.01, 0.1 and 1 mg/kg b.w.) was orally administered once daily from 7 days before to 7 days after the Aβ25-35 injection, and the Y-maze test was performed 7 days after the Aβ25-35 injection (n =: 15 per group). We subsequently examined the effect of LNDP on the gene expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) in the hippocampus using real-time polymerase chain reaction. Intracerebroventricular injection of Aβ25-35 induced memory impairment in the mice, whereas oral administration of LNDP improved memory impairment without significantly affecting the locomotor response. We also demonstrated that oral administration of LNDP increased BDNF, NGF and NT-3 mRNA expression in the hippocampus. These results suggest that LNDP may be useful in the prevention or treatment of neurodegenerative disorders such as Alzheimer's disease and may be linked to BDNF, NGF and NT-3 expression in the hippocampus.
- Subjects
ALZHEIMER'S disease; AMYLOID plaque; NEUROTROPHINS; GENE expression; NEURODEGENERATION; NERVE growth factor
- Publication
Pharmacometrics / Ōyō Yakuri (0300-8533), 2018, Vol 95, Issue 1/2, p9
- ISSN
0300-8533
- Publication type
Article