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- Title
Endocytosis: Joint efforts of ESCRTs.
- Authors
Heinrichs, Arianne
- Abstract
The article reports on the study that determines the crystal structure of endosomal sorting complex required for transport (ESCRT)-II and ESCRT-III. It shows that cargo proteins are incorrectly sorted in yeast strains that express binding-defective VPS20 or VPS25 mutants. It suggests that the ESCRT-II and ESCRT-III interaction is essential for sorting cargo proteins. It proposes that the ESCRT-II VPS202 super complex might promote negative membrane curvature by functioning as a scaffold.
- Subjects
ENDOCYTOSIS; ENDOSOMES; YEAST; BIOMOLECULES; PROTEINS; CURVATURE
- Publication
Nature Reviews Molecular Cell Biology, 2009, Vol 10, Issue 9, p581
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2757