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- Title
Antioxidant properties of some novel derivatives thiazolo[4,5-b] pyridine.
- Authors
Chaban, Taras; Ogurtsov, Volodymyr; Mahlovanyy, Anatoliy; Sukhodolska, Natalia; Chaban, Ihor; Harkov, Stefan; Matiychuk, Vasyl
- Abstract
The synthesis and determination of the antioxidant activity of some novel (5,7-dimethyl-2-oxo-thiazolo[4,5-b]pyridine-3-yl)-acetic acid hydrazide derivatives are described in this article. The transformation of the base heterocycle was carried out via the reactions of acylation, [2+3]cyclocondensation, Knoevenagel condencation and alkylation for the purpose to obtain substances with a satisfactory pharmacological profile. Antioxidant activity of the synthesized compounds was evaluated in vitro by means of the scavenging metod effect on 2,2 diphenyl-1-picrylhydrazyl (DPPH) radicals.
- Subjects
ANTIOXIDANTS; HETEROCYCLIC compounds; RADICALS; ALKYLATION; ACYLATION
- Publication
Pharmacia (0428-0296), 2019, Vol 66, Issue 4, p171
- ISSN
0428-0296
- Publication type
Article
- DOI
10.3897/pharmacia.66.e36764