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- Title
<sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography to Evaluate Cervical Node Metastases in Patients With Head and Neck Squamous Cell Carcinoma: A Meta-analysis.
- Authors
Kyzas, Panayiotis A.; Evangelou, Evangelos; Denaxa-Kyza, Despina; Loannidis, John P. A.
- Abstract
Background Positron emission tomography using 18F-fluorodeoxyglucose (18F-FDG PET) has been proposed to enhance preoperative assessment of cervical lymph node status in patients with head and neck squamous cell carcinoma (HNSCC). Management is most controversial for patients with a clinically negative (cNO) neck. We aimed to assess the diagnostic accuracy of 18F-FDG PET in detecting lymph node metastases in patients with HNSCC. Methods We performed a meta-analysis of all available studies of the diagnostic performance of 18F-FDG PET in patients with HNSCC. We determined sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves using hierarchical regression models. We also compared the performance of 18F-FDG PET with that of conventional diagnostic methods (ie, computed tomography, magnetic resonance imaging, and ultra- sound with fine-needle aspiration) by analyzing studies that had also used these diagnostic methods on the same patients. Results Across 32 studies (1236 patients), 18F-FDG PET sensitivity was 79% (95% confidence interval [Cl] = 72% to 85%) and specificity was 86% (95% CI = 83% to 89%). For cNO patients, sensitivity of 18F-FDG PET was only 50% (95% Cl = 37% to 63%), whereas specificity was 87% (95% Cl = 76% to 93%). Overall, LR+ was 5.84 (95% Cl = 4.59 to 7.42) and LR- was 0.24 (95% Cl = 0.17 to 0.33). In studies in which both 18F-FDG PET and conventional diagnostic tests were performed, sensitivity and specificity of 18F-FDG PET were 80% and 86%, respectively, and of conventional diagnostic tests were 75% and 79%, respectively. Conclusion 18F-FDG PET has good diagnostic performance in the overall pretreatment evaluation of patients with HNSCC but still does not detect disease in half of the patients with metastasis and cNO.
- Subjects
POSITRON emission tomography; METASTASIS; SQUAMOUS cell carcinoma; LYMPH node diseases; META-analysis; MAGNETIC resonance imaging; PATIENTS
- Publication
JNCI: Journal of the National Cancer Institute, 2008, Vol 100, Issue 10, p712
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djn125