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- Title
PW01-254 - Risk factors for suicide in the observational schizophrenia outpatient health outcomes (SOHO) study
- Authors
Novick, D.; Brugnoli, R.; Haro, J.M.; Rossi, A.; Bortolomasi, M.; Frediani, S.; Borgherini, G.
- Abstract
Objectives: To identify factors associated with suicide attempts using data from a large, 3-year, multinational follow-up study of schizophrenia (SOHO study). Methods: All baseline characteristics of 8,871 adult patients with schizophrenia collected in patients included in the SOHO study were included in a GEE logistic regression post-hoc analysis comparing patients who attempted suicide during the study with those who did not. Results: A total of 384 (4.3%) patients attempted or committed suicide. The risk factors that resulted statistically associated with suicide attempt were a lifetime history of suicide attempts (OR 3.6 [95% CI 2.8, 4.6; p< 0.0001]), suicide attempts in the last 6 months (OR 2.5 [95% CI 1.8, 3.4; p< 0.0001]), prolactin-related side effects (OR 2.0 [95%CI 1.4, 2.9; p=0.0002]), CGI depression (OR 1.2 [95% CI 1.1, 1.3; p=0.0004]) and history of hospitalization for schizophrenia (OR 1.4 [95% CI 1.1, 1.8; p=0.009]). Conclusions: In view of the observational design of the study and the post-hoc nature of the analysis, the identified risk factors should be confirmed by ad-hoc specifically designed studies.
- Subjects
SUICIDE risk factors; SCHIZOPHRENIA; HEALTH outcome assessment; OUTPATIENT services in psychiatric hospitals; PEOPLE with schizophrenia; FOLLOW-up studies (Medicine); LOGISTIC regression analysis
- Publication
European Psychiatry, 2010, Vol 25, p1682
- ISSN
0924-9338
- Publication type
Abstract
- DOI
10.1016/S0924-9338(10)71661-8