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- Title
Comparison of 70/30 Biphasic Insulin With Glargine/Lispro Regimen in Non–Critically Ill Diabetic Patients on Continuous Enteral Nutrition Therapy.
- Authors
Hsia, Elisa; Seggelke, Stacey A.; Gibbs, Joanna; Rasouli, Neda; Draznin, Boris
- Abstract
Despite significant advances in inpatient diabetes management, it is still a challenge to choose the safest and most efficacious subcutaneous insulin regimen for diabetic patients on continuous enteral nutrition (EN) therapy. The authors conducted a retrospective analysis of glycemic control in 22 non–critically ill diabetic patients, receiving at least 3 days of continuous EN. Patients received different insulin regimens while on continuous EN, including a basal/bolus glargine/lispro regimen (group 1, n = 8), 70/30 biphasic insulin twice daily (group 2, n = 8), and 70/30 biphasic insulin 3 times a day (group 3, n = 6). The glucose data from 72 hours from the initiation of EN were analyzed (12 point-of-contact glucose measurements per patient). Overall, the degree of control was comparable in all groups, with target range maintained more consistently in group 3 (70/30 insulin administered 3 times daily). In this group, 69% of values were in the target range (140–180 mg/dL) as compared with 24% in glargine/lispro group and 22% in the 70/30 insulin bid group. Eight hypoglycemic episodes occurred among the 3 groups: 5 episodes in group 1 (5.4%), 2 episodes in group 2 (2.1%), and 1 episode in group 3 (1.4%) (P = .05, groups 2 and 3 vs group 1). Administration of 70/30 biphasic insulin 3 times daily is a safe therapeutic regimen in diabetic patients on continuous EN as it maintains glycemia in the target range and might produce fewer episodes of hypoglycemia.
- Subjects
COLORADO; BLOOD sugar analysis; TREATMENT of diabetes; ACADEMIC medical centers; CHI-squared test; COMPARATIVE studies; DIABETES; ENTERAL feeding; GLYCOSYLATED hemoglobin; HOSPITAL care; INSULIN; METABOLIC regulation; T-test (Statistics); RETROSPECTIVE studies; DESCRIPTIVE statistics
- Publication
Nutrition in Clinical Practice, 2011, Vol 26, Issue 6, p714
- ISSN
0884-5336
- Publication type
Article
- DOI
10.1177/0884533611420727