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- Title
SINGLE NUCLEOTIDE POLYMORPHISM OF IL9 + 176 (RS1799962) IN A SAMPLE OF ASTHMA IN IRAQI PATIENTS.
- Authors
Hassan, Ibtisam Badday; Ali, Olaa Moyad; Alwan, Adnan Hasan
- Abstract
The present study aimed at investigating of frequency of polymorphism of interleukin-9 gene (IL9) at position176+SNP) in and in healthy controls subjects beginning of the month October (2020) to the end of March (2021), The study included 74 patients suffering from asthma with an average age of (43.16 ± 2.14), the number of males was (26) and the percentage of (40.6 %) and the number of females was (38) and the rate of (59.4 %), while the control group included (26) apparently healthy people with a rate of My age is (38.35 ± 2.22), if the number of males is (21) with a percentage (80.8%) and the number of females is (5) with a percentage (19.2%) were enrolled in this study, the polymorphism of IL9176+ was data waved by polymerase chain reaction-specific sequence primer (PCR-SSP) assay. The results showed a comparison IL9176+ genotypes & alleles between asthma patients & controls frequencies of CC genotype & C allele 21.67, 20.0%) P = 0.219, respectively). There was a significant increase in patients contrast to controls, (7.5 vs. 5.0%; P = 0.093) and associated EF rates were 4.75 & 3.41 respectively. And the In contrast TT genotype & T allele (%76,67 vs. 78.33%, P = 0.258, respectively). Low frequency was observed in patients compared to healthy subjects (90.00% vs. 92.50%; P = 0.093) and the related PF values were 0.37 & 0.29, respectively. Similar observations were made in TC genotype. The study results indicate that the IL9+176 SNP may have a role in events and development of asthma in Iraqi patients.
- Subjects
SINGLE nucleotide polymorphisms; ASTHMATICS; INTERLEUKIN-9; GENOTYPES; GENETICS of asthma
- Publication
Biochemical & Cellular Archives, 2021, Vol 21, Issue 2, p3821
- ISSN
0972-5075
- Publication type
Article