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- Title
COMPARATIVE APPRECIATION OF PARAOXONASE ACTIVITY IN IRAQI WOMEN WITH TOXOPLASMOSIS.
- Authors
Zainulabdeen, Jwan Abdulmohsin
- Abstract
Role of the paraoxonase (PON) as a member of the anti-oxidant defense system with the incidence of Toxoplasmosis was assessed in 80 Iraqi women (50% fertile and 50% infertile). Eighty blood samples were collected from infertile women (as patients, P group) and apparently healthy fertile women (as control, C group), their ages between (20-40) years. Each group was subdivided into two groups: with seropositive Toxoplasma gondii IgG group (PP and PC for patient and control group, respectively) and seronegative toxoplasma gondii IgG (NP and NC for patient and control group, respectively). Paraoxonase (PON) activity, Vitamin D concentration (Vit. D) was estimated in sera of women for each collected sample. In the seronegative fertile women group when compared with the adjusted infertile subject groups, there was a non- significant increase in serum IgG level and PON activity (p>0.05), whereas the result was significant (p<0.05) for Vit. D levels. A highly significant increase (p<0.001) in serum IgG concentration and PON activity for seropositive infertile women in comparison with that of fertile were observed; in contrast the result was a highly significant decrease (p<0.001) in vit. D levels in this comparison. Based on the results of this study the proposed antioxidant role of PON1 was proved in toxoplasmosis disease, which involved oxidative stress that affected women's fertility, as well the effect of Vit D as an exogenous antioxidant was confirmed.
- Subjects
PARAOXONASE; TOXOPLASMOSIS treatment; THERAPEUTIC use of vitamin D; IMMUNOGLOBULIN G; FERTILITY
- Publication
Biochemical & Cellular Archives, 2020, Vol 20, Issue 2, p5933
- ISSN
0972-5075
- Publication type
Article