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- Title
Pain mechanisms in adults with haemophilia: A research protocol of a cross-sectional study.
- Authors
Foubert, A.; Chantrain, V-A; Meeus, M.; Hermans, C.; Lambert, C.; Lobet, S.; N., Roussel
- Abstract
Introduction: Haemophilic arthropathy is the hallmark of people with haemophilia (PwH) causing morbidity and (chronic) pain.(1) It has recently became evident that clinical pain experience in the majority of chronic musculoskeletal conditions results from alterations in peripheral and central pain mechanisms.(2) However, evidence exploring these pain mechanisms by use of quantitative evaluation of the somatosensory system and endogenous pain modulation is still scarce in PwH.(3) Methods: One hundred adults with moderate to severe haemophilia A or B between 18 and 65 years and thirty age-matched healthy controls were recruited. They underwent a Quantitative Sensory Testing (QST) protocol to assess the function of the somatosensory system, statically to evaluate pain sensitivity and dynamically with conditioned pain modulation (CPM) paradigm to examine the function of endogenous pain inhibition. Synovial joints, forehead and wrist as reference locations were examined. Results: We hypothesize that PwH will demonstrate a combination of peripheral sensitization, more widespread alterations of the somatosensory system suggestion central sensitization and reduced endogenous pain inhibitory efficacy compared to healthy controls. Discussion: In line with other chronic musculoskeletal conditions we expect, at least in a subgroup of PwH, altered somatosensory functioning and impaired efficacy of endogenous pain inhibition. Process evaluation: Since pain research and especially clinical pain assessments are new in this population, we have no evidenced haemophilia-specific protocols. However, since the clinical presentation of haemophilic arthropathy is very similar to osteoarthritis, we followed validated protocols for other musculoskeletal conditions. Like many other studies, our recruitment process was also hampered by the COVID-pandemic.
- Subjects
NETHERLANDS; HEMOPHILIA; PAIN; RESEARCH protocols; CONFERENCES &; conventions; ADULTS
- Publication
Pain Practice, 2022, Vol 22, p19
- ISSN
1530-7085
- Publication type
Article
- DOI
10.1111/papr.13128