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- Title
ESTUDIO FITOQUÍMICO, TOXICIDAD AGUDA Y EFECTOS ANTIULCEROSO Y ANTITUMORAL DE LOS EXTRACTOS ACUOSO, ETANÓLICO Y METANÓLICO DE Capsicumpubescens, «Rocoto».
- Authors
Benjamín, Castañeda C.; Alberto, Salazar G.**
- Abstract
Objective: To evaluate the chemical composition, the acute toxicity and antiulcer and antitumor effects of three extracts from Capsicumpubescens (ROCOTO) in pre-clinical studies. Materials and methods: Experimental pre-clinical, analytical study. We used 50 male albino rats to assess the antiulcer effect, and 86 albino mice were used to evaluate the anti-tumoral effect and acute toxicity. The phytochemical sieved was carried out with the Ciulei method. Indomethacin was used as an ulcerous agent to produce gastric ulcers. The Antitumor effect of Capsicumpubescens, was evaluated against sarcoma-180. Acute toxicity (DL-50) was evaluated with doses of 500, 1000, 2000, 10000 and 12000 mg/kg weight of the hot pepper. Results: In the phytochemical study, we detected fats, oils, alkaloids, lactones, coumarins, triterpenes, steroids, catechin, resins, reducing sugars, phenols and tannins, among others. We observed the reduction of macroscopic gastric lesions produced by indomethacin with the aqueous and ethanolic extracts of rocoto, superior to those of ranitidine. We did not observe mortality in mice up to the dose of 12,000 mg/kg weight of rocoto's methanol extract. The rocoto methanolic extract, improved the survival of mice inoculated with sarcoma, when given preventively, being the effect greater at a dose of 750 mg/kg. Conclusions: The aqueous and ethanolic extracts of rocoto, showed gastroprotective properties, dose-dependent, superior to ranitidine; and the methanol extract presented an antitumor effect against sarcoma-180, administered temporarily and it is practically non-toxic according to the Williams criteria.
- Subjects
TOXICOLOGY; ANTINEOPLASTIC agents; ANTIULCER drugs; PHYTOCHEMICALS; PEPTIC ulcer; INDOMETHACIN
- Publication
Cultura: Revista de la Asociación de Docentes de la USMP, 2014, Vol 28, p317
- ISSN
1817-0285
- Publication type
Article