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- Title
Unraveling bias in survival of patients with incidentally discovered low-grade gliomas.
- Authors
Johnson, Derek R
- Abstract
Common measures of outcome such as progression-free survival and overall survival (OS), which are vitally important for patient counseling and treatment selection, tend to begin accruing at the time of surgical diagnosis and ignore the typically brief interval between symptom onset and surgery. Controlling for lead-time bias and length-time bias, patients with iLGG still had longer OS than patients with symptomatic LGG, though the magnitude of the survival difference was reduced. Most patients diagnosed with primary brain tumors present with symptoms, for example, progressive focal neurological deficits in patients with high-grade gliomas or seizures in patients with low-grade gliomas (LGG).
- Subjects
OVERALL survival; BRAIN tumors; GLIOMAS
- Publication
Neuro-Oncology Practice, 2023, Vol 10, Issue 2, p109
- ISSN
2054-2577
- Publication type
Article
- DOI
10.1093/nop/npad002