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- Title
Age-Related Characteristics of Sleep Impairments in a Model of the Preclinical Stage of Parkinson's Disease in Rats.
- Authors
Ekimova, I. V.; Guzeev, M. A.; Simonova, V. V.; Pastukhov, Yu. F.
- Abstract
Objective. To assess changes in the time characteristics of the states of sleep and waking which may serve as nonmotor signs of the initial stage of PD using a model of the preclinical stage of Parkinson's disease (BP) in Wistar rats of different ages. Materials and methods. A model of the prolonged (up to 21 days) preclinical stage of PD in middle-aged (6–7 months) and elderly (19–20 months) rats was created using increasing suppression of the proteasome system of the brain by intranasal administration of the specific proteasome inhibitor lactacystin. Continuous (24 h) computerized recording of polysomnograms including body temperature was performed using a Dataquest A.R.T. System telemetry system (DSI, USA) with the animals in conditions of free behavior. Results and conclusions. The results obtained here showed that aging produced a two-fold increase in sleepiness in the active (dark) period of the day and a 1.5-fold increase in the content of shallow sleep in the inactive phase. Hypersomnia in the active period of the day, comparable with excessive daytime sleepiness syndrome in humans, was identified as a sign of sleep impairment in the model of preclinical PD common to middle-aged and elderly animals. This syndrome was more marked in elderly animals, as it appeared on the background of age-related increases in sleepiness. The model of the preclinical stage of PD in middle-aged and elderly rats demonstrated reduced δ-wave activity in slow-wave sleep as a dangerous syndrome, where increasing inhibition of the proteasome system of the brain decreases the rate of protein synthesis and reduces the activity of restorative processes in nerve cells. Sleep impairments seen in the model of the preclinical stage of PD in rats of different ages can be recommended for validation in clinical trials as an early and low-cost marker for the initial stages of PD.
- Subjects
PARKINSON'S disease; RAT diseases; HYPERSOMNIA; ANIMAL models in research; LABORATORY rats; INTRANASAL administration
- Publication
Neuroscience & Behavioral Physiology, 2021, Vol 51, Issue 6, p704
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-021-01124-z