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- Title
Crystallographic studies of the extracytoplasmic function σ factor σ<sup>J</sup> from Mycobacterium tuberculosis.
- Authors
Goutam, Kapil; Gupta, Arvind Kumar; Gopal, Balasubramanian
- Abstract
Mycobacterium tuberculosis has multiple σ factors which enable the bacterium to reprogram its transcriptional machinery under diverse environmental conditions. σJ, an extracytoplasmic function σ factor, is upregulated in late stationary phase cultures and during human macrophage infection. σJ governs the cellular response to hydrogen peroxide-mediated oxidative stress. σJ differs from other canonical σ factors owing to the presence of a SnoaL_2 domain at the C-terminus. σJ crystals belonged to the tetragonal space group I422, with unit-cell parameters a = b = 133.85, c = 75.08 Å. Diffraction data were collected to 2.16 Å resolution on the BM14 beamline at the European Synchrotron Radiation Facility (ESRF).
- Subjects
BACTERIAL protein crystallography; MYCOBACTERIUM tuberculosis; OXIDATIVE stress; SIGMA factor (Transcription factor); C-terminal binding proteins; SYNCHROTRON radiation; BACTERIA
- Publication
Acta Crystallographica: Section F, Structural Biology Communications, 2015, Vol 71, Issue 8, p946
- ISSN
2053-230X
- Publication type
Article
- DOI
10.1107/S2053230X15009577