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- Title
Relationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis.
- Authors
Chang, Christina C.; Kangethe, Richard; Omarjee, Saleha; Hiramen, Keshni; Gosnell, Bernadett; Sojane, Katlego; Moosa, Mohamed-Yunus S.; Lewin, Sharon R.; French, Martyn A.; Ndung'u, Thumbi
- Abstract
We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal fluid HIV RNA was lower than in plasma (median 4.7 vs 5.2 log10 copies/mL, P < .0001) and positively correlated with plasma HIV RNA, peripheral CD4+ T-cell percentage, and CSF CXCL10. Plasma/CSF ratio of HIV RNA ranged widely from 0.2 to 265.5 with a median of 2.6. Cerebrospinal fluid quantitative cryptococcal culture positively correlated with CSF CCL2 and CCL3. CSF-plasma viral discordance was not associated with cryptococcal-associated immune reconstitution inflammatory syndrome.
- Subjects
HIV-positive persons; THERAPEUTICS; HIV infections; RNA analysis
- Publication
Open Forum Infectious Diseases, 2017, Vol 4, Issue 2, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofx032