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- Title
Posterior midline activation during symptom provocation in acute stress disorder: an fMRI study.
- Authors
Cwik, Jan C.; Sartory, Gudrun; Schürholt, Benjamin; Knuppertz, Helge; Seitz, Rüdiger J.; Villalta-Gil, Victoria; Radua, Joaquim; Amann, Benedikt L.
- Abstract
Functional imaging studies of patients with post-traumatic stress disorder showed widespread activation of midline cortical areas during symptom provocation, i.e., exposure to trauma-related cues.The present study aimed at investigating neural activation during exposure to trauma-related pictures in patients with acute stress disorder (ASD) shortly after the traumatic event. Nineteen ASD patients and 19 healthy control participantswere presented with individualized pictures of the traumatic event and emotionally neutral control pictures during the acquisition of whole-brain data with a 3-T fMRI scanner. Compared to the control group and to control pictures, ASD patients showed significant activation in midline cortical areas in response to trauma-related pictures including precuneus, cuneus, postcentral gyrus, and pre-supplementary motor area. The results suggest that the trauma-related pictures evoke emotionally salient self-referential processing in ASD patients.
- Subjects
ACUTE stress disorder; POST-traumatic stress disorder; PROVOCATION tests (Medicine); TRAUMATISM; FUNCTIONAL magnetic resonance imaging; PSYCHOLOGY
- Publication
Frontiers in Psychiatry, 2014, Vol 5, p1
- ISSN
1664-0640
- Publication type
Article
- DOI
10.3389/fpsyt.2014.00049