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- Title
p38α controls self-renewal and fate decision of neurosphere-forming cells in adult hippocampus.
- Authors
Yoshioka, Kento; Namiki, Kana; Sudo, Tatsuhiko; Kasuya, Yoshitoshi
- Abstract
Neural stem cells (NSC) from the adult hippocampus easily lose their activity in vitro . Efficient in vitro expansion of adult hippocampus-derived NSC is important for generation of tools for research and cell therapy. Here, we show that a single copy disruption or pharmacological inhibition of p38α enables successful long-term neurosphere culture of adult mouse hippocampal cells. Expanded neurospheres with high proliferative activity differentiated into the three neuronal lineages under differentiating conditions. Thus, inhibition of p38α can maintain adult hippocampal NSC activity in vitro .
- Subjects
HIPPOCAMPUS (Brain); NEUROGLIA; NEURAL stem cells; DENTATE gyrus; IN vitro studies
- Publication
FEBS Open Bio, 2015, Vol 5, p437
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1016/j.fob.2015.05.001