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- Title
Chemical and microbiological stability of diluted ceftazidime in three different solutions under three storage temperatures over a 28 day period.
- Authors
Hoff, Sarah E.; Berger, Darren J.; Viall, Austin K.; Schrunk, Dwayne; Noxon, James O.
- Abstract
B Background - b Ceftazidime (CAZ) solutions are being used based on anecdotal reports for otitis externa complicated by multidrug-resistant I Pseudomonas aeruginosa i (MDR PA). At any given time point and storage temperature, the RCCs for TE+CAZ solutions were significantly lower than those for NA+CAZ and MI+CAZ solutions. Triz, 118 mL Triz-EDTA Aqueous flush + 1 g Ceftazidime (CAZ) compounded solution; Micellar, 125 mL Douxo Micellar Solution + 1 g CAZ compounded solution; NaCl, 100 mL 0.9% NaCl + 1 g CAZ compounded solution. Discussion This study shows that compounded CAZ solutions have variability in the chemical stability of CAZ, influenced by storage duration, storage temperature and base diluent.
- Subjects
CEFTAZIDIME; CHEMICAL stability; GERMAN shepherd dog; PSEUDOMONAS aeruginosa infections
- Publication
Veterinary Dermatology, 2021, Vol 32, Issue 5, p456
- ISSN
0959-4493
- Publication type
Abstract
- DOI
10.1111/vde.12997