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- Title
Effects of Adrenomedullin, Calcitonin Gene-Related Peptide, and Amylin on Cerebral Circulation in Dogs.
- Authors
Baskaya, Mustafa K.; Suzuki, Yoshio; Anzai, Masaoki; Seki, Yukio; Saito, Kiyoshi; Takayasu, Masakazu; Shibuya, Masato; Sugita, Kenichiro
- Abstract
Summary: The effect of human adrenomedullin on cerebral circulation was investigated in dogs in vivo and in vitro. Bolus administration of adrenomedullin or its homologous peptides, calcitonin gene-related peptide (CGRP) and amylin, into the vertebral artery induced a dose-dependent increase in vertebral blood flow. The potencies of adrenomedullin and CGRP were similar and approximately 100 times more than that of amylin. The effects of adrenomedullin and CGRP were inhibited by CGRP8-37, an antagonist of CGRP. In contrast to substance P, adrenomedullin did not induce an increase in blood flow after prior administration of CGRP. Pretreat-ment with either NG-nitro-L-arginine methyl ester or in-domethacin did not affect the adrenomedullin-induced increase in blood flow. Intracisternal administration of adrenomedullin induced dilation of the basilar and other major cerebral arteries in a dose-dependent manner, accompanied by an increase in the concentration of cyclic AMP in the cerebrospinal fluid. Adrenomedullin also induced relaxation of isolated basilar and middle cerebral arterial rings. These data suggest that adrenomedullin induces vasodilation of cerebral arteries and an increase in vertebral blood by acting at CGRP receptors positively coupled to adenylate cyclase, and that these effects are not dependent on nitric oxide or prostaglandin formation.
- Publication
Journal of Cerebral Blood Flow & Metabolism, 1995, Vol 15, Issue 5, p827
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.1995.103