We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TRP channels: a provocative rationalization for local Ca<sup>2+</sup> control in arterial tone development.
- Authors
El-Lakany, Mohammed A.; Welsh, Donald G.
- Abstract
Arterial networks are controlled by the consolidated output of stimuli that set "how much" (magnitude) and "where" (distribution) blood flow is delivered. While notable changes in magnitude are tied to network wide responses, altered distribution often arises from focal changes in tone, whose mechanistic foundation remains unclear. We propose herein a framework of focal vasomotor contractility being controlled by pharmacomechanical coupling and the generation of Ca2+ waves via the sarcoplasmic reticulum. We argue the latter is sustained by receptor operated, transient receptor potential (TRP) channels through direct extracellular Ca2+ influx or indirect Na+ influx, reversing the Na+/Ca2+ exchanger. We view this focal regulatory mechanism as complementary, but not redundant with, electromechanical coupling in the precision tuning of blood flow delivery.
- Subjects
TRP channels; BLOOD flow; SARCOPLASMIC reticulum; ION channels
- Publication
Frontiers in Physiology, 2024, p01
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2024.1374730