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- Title
Optimization of Cultural Conditions for Production of Antibacterial Metabolites from Streptomyces coelicoflavus BC 01.
- Authors
RAGHAVA RAO, Kothagorla Venkata; BHASKARA RAO, Dadi; SATYANARAYANA, Botcha; RAGHAVA RAO, Tamanam
- Abstract
The aim of the present study was to optimize various cultural conditions for die production of antibacterial metabolites by Streptomyces coelkoflavus BC 01 isolated from mangrove soil, Visakhapatnam, Andhra Pradesh, India. The effect of various factors such as carbon and nitrogen sources, different concentrations of NaCI and K2HPO4, different temperature, pH, incubation time and agitation on antibacterial metabolites production were studied. The production of antibacterial metabolites by the isolate Streptomyces coelkoflavus BC 01 was greatly influenced by the cultural conditions. Glucose (1.2%) and soya bean meal (1%) seemed to be the best carbon and nitrogen source respectively, followed by NaCI (1%) and K2HPO4 (0.25%). Maximum production of antibacterial metabolites was observed at a temperature of 30 °C, with pH 7.2, at 160 rpm for 96 hrs. These optimized parameters can be further useful to design a fermentation medium to achieve maximum yield of antibacterial metabolites from Streptomyces coelicoflavus BC 01.
- Subjects
STREPTOMYCES; BACTERIAL metabolites; ANTIBACTERIAL agents; EFFECT of carbon on plants; EFFECT of nitrogen on plants; VIRUS isolation
- Publication
Notulae Scientia Biologicae, 2015, Vol 7, Issue 2, p151
- ISSN
2067-3205
- Publication type
Article
- DOI
10.15835/nsb729481