We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Prospective Study to Investigate Predictors of Relapse among Patients with Opioid Use Disorder Treated with Methadone.
- Authors
Naji, Leen; Dennis, Brittany B.; Bawor, Monica; Plater, Carolyn; Pare, Guillaume; Worster, Andrew; Varenbut, Michael; Daiter, Jeff; Marsh, David C.; Desai, Dipika; Thabane, Lehana; Samaan, Zainab
- Abstract
INTRODUCTION: Concomitant opioid abuse is a serious problem among patients receiving methadone maintenance treatment (MMT) for opioid use disorder. This is an exploratory study that aims to identify predictors of the length of time a patient receiving MMT for opioid use disorder remains abstinent (relapse-free). METHODS: Data were collected from 250 MMT patients enrolled in addiction treatment clinics across Southern Ontario. The impact of certain clinical and socio-demographic factors on the outcome (time until opioid relapse) was determined using a Cox proportional hazard model. RESULTS: History of injecting drug use behavior (hazard ratio (HR): 2.26, P = 0.042), illicit benzodiazepine consumption (HR: 1.07, P = 0.002), and the age of onset of opioid abuse (HR: 1.10, P < 0.0001) are important indicators of accelerated relapse among MMT patients. Conversely, current age is positively associated with duration of abstinence from illicit opioid use, serving as a protective factor against relapse (HR: 0.93, P = 0.003). CONCLUSION: This study helps to identify patients at increased risk of relapse during MMT, allowing health care providers to target more aggressive adjunct therapies toward high-risk patients.
- Subjects
AGE factors in disease; LONGITUDINAL method; METHADONE hydrochloride; RESEARCH; SUBSTANCE abuse; TIME; DISEASE relapse; LONG QT syndrome; INTRAVENOUS drug abusers; PROPORTIONAL hazards models; DESCRIPTIVE statistics
- Publication
Substance Abuse: Research & Treatment, 2016, Vol 10, p9
- ISSN
1178-2218
- Publication type
Article
- DOI
10.4137/SART.S37030