We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Filling the Silent Void: Genetic Therapies for Hearing Impairment.
- Authors
Joel Sng; Lufkin, Thomas
- Abstract
The inner ear cytoarchitecture forms one of the most intricate and delicate organs in the human body and is vulnerable to the effects of genetic disorders, aging, and environmental damage. Owing to the inability of the mammalian cochlea to regenerate sensory hair cells, the loss of hair cells is a leading cause of deafness in humans. Millions of individuals worldwide are affected by the emotionally and financially devastating effects of hearing impairment (HI). This paper provides a brief introduction into the key role of genes regulating inner ear development and function. Potential future therapies that leverage on an improved understanding of these molecular pathways are also described in detail.
- Subjects
TREATMENT of hearing disorders; CYTOARCHITECTONICS; INNER ear diseases; GENETIC disorders; AGING; HAIR cell regeneration; GENETIC regulation
- Publication
Genetics Research International, 2012, p1
- ISSN
2090-3154
- Publication type
Article
- DOI
10.1155/2012/748698