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- Title
Atypical Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in Denmark: A Diagnostic Mimicker.
- Authors
HORSTEN, Hans-Henrik; KEMP, Michael; FISCHER, Thea K.; LINDAHL, Kim H.; BYGUM, Anette
- Abstract
Since 2008, outbreaks of atypical hand, foot, and mouth disease (HFMD) in children and adults have been reported worldwide. The majority of these outbreaks are caused by a new lineage of Coxsackie virus A6 (CV-A6) presenting a more severe clinical phenotype than the classical childhood HFMD caused by CVA16. Between June 2014 and January 2016, 23 cases of atypical HFMD disease presented at a Dermatology Department at a regional University Hospital in Denmark. Patients were referred by general practitioners and dermatologists with a variety of clinical diagnoses, including eczema herpeticum, vasculitis, syphilis, dermatophytid, erythema multiforme and Stevens-Johnson syndrome. Three adults and 3 children required hospitalization due to extensive skin involvement and fever. All reported patients had laboratory-confirmed enterovirus infection. This study demonstrated an upsurge in atypical HFMD caused by CV-A6 in the Region of Southern Denmark and that atypical HFMD can be difficult to diagnose clinically as it may mimic other severe skin diseases.
- Subjects
DENMARK; DIAGNOSIS of foot &; mouth disease; COXSACKIEVIRUSES; PANDEMICS; KAPOSI varicelliform eruption; HOSPITAL care; UNIVERSITY hospitals
- Publication
Acta Dermato-Venereologica, 2018, Vol 98, Issue 3, p350
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-2853