We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Predictive biomarkers for immune checkpoint inhibitor response in urothelial cancer.
- Authors
Parent, Pauline; Marcq, Gautier; Adeleke, Sola; Turpin, Anthony; Boussios, Stergios; Rassy, Elie; Penel, Nicolas
- Abstract
Immune checkpoint inhibitors (ICIs) are commonly used to treat patients with advanced urothelial cancer. However, a significant number of patients do not respond to ICI, and the lack of validated predictive biomarkers impedes the success of the ICI strategy alone or in combination with chemotherapy or targeted therapies. In addition, some patients experience potentially severe adverse events with limited clinical benefit. Therefore, identifying biomarkers of response to ICI is crucial to guide treatment decisions. The most evaluated biomarkers to date are programmed death ligand 1 expression, microsatellite instability/defective mismatch repair phenotype, and tumor mutational burden. Other emerging biomarkers, such as circulating tumor DNA and microbiota, require evaluation in clinical trials. This review aims to examine these biomarkers for ICI response in urothelial cancer and assess their analytical and clinical validation.
- Publication
Therapeutic Advances in Medical Oncology, 2023, p1
- ISSN
1758-8340
- Publication type
Article
- DOI
10.1177/17588359231192402