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- Title
Exploiting the dynamic properties of covalent modification cycle for the design of synthetic analog biomolecular circuitry.
- Authors
Foo, Mathias; Sawlekar, Rucha; Bates, Declan G.
- Abstract
Background: Cycles of covalent modification are ubiquitous motifs in cellular signalling. Although such signalling cycles are implemented via a highly concise set of chemical reactions, they have been shown to be capable of producing multiple distinct input-output mapping behaviours -- ultrasensitive, hyperbolic, signal-transducing and threshold-hyperbolic. Results: In this paper, we show how the set of chemical reactions underlying covalent modification cycles can be exploited for the design of synthetic analog biomolecular circuitry. We show that biomolecular circuits based on the dynamics of covalent modification cycles allow (a) the computation of nonlinear operators using far fewer chemical reactions than purely abstract designs based on chemical reaction network theory, and (b) the design of nonlinear feedback controllers with strong performance and robustness properties. Conclusions: Our designs provide a more efficient route for translation of complex circuits and systems from chemical reactions to DNA strand displacement-based chemistry, thus facilitating their experimental implementation in future Synthetic Biology applications. Keywords: Covalent modification cycle, Chemical reaction networks, Analog synthetic biomolecular circuits, Linear and nonlinear operators, Feedback control systems, Synthetic biology applications
- Subjects
CHEMICAL reactions; FEEDBACK control systems; NONLINEAR operators; SYNTHETIC biology; BIOENGINEERING
- Publication
Journal of Biological Engineering, 2016, Vol 10, p1
- ISSN
1754-1611
- Publication type
Article
- DOI
10.1186/s13036-016-0036-1