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- Title
A Case of Chronic Myelomonocytic Leukemia with Severe Eosinophilia Having t(5;12)(q31;p13) with t(1;7)(q10;p10).
- Authors
Myungshin Kim; Jihyang Lim; Ahwon Lee; Gyeongsin Park; Yonggoo Kim; Kyungja Han; Chang Suk Kang; Yoo-Jin Kim; Jeong-Sup Song
- Abstract
We describe an unusual case of chronic myelomonocytic leukemia with severe eosinophilia having t(5;12)(q31;p13) with t(1;7)(q10;p10). The eosinophilic proliferation was severe in peripheral blood and bone marrow, and they revealed marked dysplastic features. We performed fluorescence in situ hybridization (FISH) and immunohistochemistry to evaluate the clonality of eosinophils. The eosinophils were stained positively to platelet-derived growth factor receptor-β. By FISH using chromosome 1 satellite probe and chromosome 1q telomere probe, the eosinophils were proved to belong to the malignant clone. Copyright © 2005 S. Karger AG, Basel
- Subjects
CHRONIC myeloid leukemia; CHRONIC leukemia; LEUKEMIA; EOSINOPHILIA; PLATELET-derived growth factor; FLUORESCENCE in situ hybridization
- Publication
Acta Haematologica, 2005, Vol 114, Issue 2, p104
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000086584