We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Induction of Normal Human Eosinophil Migration in vitro by Substance P.
- Authors
Wiedermann, F.J.; Kähler, C.M.; Reinisch, N.; Wiedermann, C.J.
- Abstract
To investigate the role of tachykinins in allergic inflammation, the effect of substance P (SP) on normal human eosinophil migration was examined in Boy-den chamber type assays. SP stimulated eosinophil migration in vitro with an EC50 of about 1-10 pM and maximal effects were seen at 100 pM. A carboxy-terminal fragment of SP possessed appreciable activity whereas an amino-ter-minal fragment was inactive. Data represented in this paper and previous studies suggest that eosinophils are attracted by SP and activated to enhanced mediator release and cytotoxic activity. Copyright © 1993 S. Karger AG, Basel
- Publication
Acta Haematologica, 1993, Vol 89, Issue 4, p213
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000204527