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- Title
Pembrolizumab-induced obstructive bronchiolitis in a patient with stage IV non-small-cell lung cancer.
- Authors
Blanchard, A.; Bouchard, N.
- Abstract
Objective Immune checkpoint inhibitors are now a standard of care for the management of many metastatic cancers, including non-small-cell lung cancer. Pembrolizumab, a selective anti–PD-1 monoclonal antibody, augments the host antitumoural response. This hyperactivation of the immune system has side effects, the so-called immune-related adverse effects. The objective of this case report was to review and point out a new pattern of immune checkpoint inhibitor–associated pneumonitis. Case Description A 69-year-old woman with stage iv non-small-cell lung cancer receiving pembrolizumab presented for increased dyspnea. Pembrolizumab-related obstructive bronchiolitis was diagnosed based on a new severe obstructive disorder, without bronchodilator reversibility, and mosaic attenuation on angiography, without other identifiable causes. Summary To our knowledge, this is the first description of a case of pembrolizumab-induced obstructive bronchiolitis. Various patterns of immune checkpoint inhibitor–associated lung disease have been described, and bronchiolitis should be included in the differential diagnosis.
- Subjects
NON-small-cell lung carcinoma; BRONCHIOLITIS; LUNG diseases; MONOCLONAL antibodies; DRUG side effects; PNEUMONIA
- Publication
Current Oncology, 2019, Vol 26, Issue 4, pe571
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3747/co.26.4859