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- Title
Efficacy of Bupropion for Relapse Prevention in Smokers With and Without a Past History of Major Depression.
- Authors
Cox, Lisa Sanderson; Patten, Christi A.; Niaura, Raymond S.; Decker, Paul A.; Rigotti, Nancy; Sachs, David P. L.; Bulst, A. Sonia; Hurt, Richard D.
- Abstract
This study evaluated the efficacy of bupropion for relapse prevention in smokers with and without a past history of major depressive disorder. Changes in depressive symptoms were also examined. Data were gathered prospectively from a randomized, double-blind relapse prevention trial of bupropion conducted at five study sites. A total of 784 smokers (54% female, 97% white) were enrolled. Using the Structured Clinical Interview for Depression, 17% of the subjects reported a past history of major depressive disorder at baseline. All subjects received open-label bupropion SR (300 mg/d) for 7 weeks. Subjects abstinent from smoking at the end of 7 weeks ( N= 429) were randomized to bupropion SR (300 mg/d) or placebo for the remainder of the year and followed for 1 year off medication. The primary outcome measures were median time to relapse to smoking and the 7-day point-prevalence smoking abstinence rate. Self-reported abstinence from smoking was verified by expired air carbon monoxide. The Beck Depression Inventory was used to assess depressive symptoms at baseline and at weeks 8 and 12. Median time to relapse did not differ by past history of major depressive disorder. Bupropion was associated with higher point-prevalence smoking abstinence at the end of medication compared to placebo ( P= .007), independent of a past history of major depressive disorder. Moreover, change in depressive symptoms during the double-blind phase did not differ for those with and without a past history of major depressive disorder. Extended use of bupropion for relapse prevention is effective for smokers with and without a history of major depression. J GEN INTERN MED 2004;19:828–834.
- Subjects
MENTAL depression; SMOKING; SMOKING cessation; NICOTINE addiction treatment; CIGARETTE smokers; PSYCHIATRY; MENTAL health; CLINICAL trials
- Publication
JGIM: Journal of General Internal Medicine, 2004, Vol 19, Issue 8, p828
- ISSN
0884-8734
- Publication type
Article
- DOI
10.1111/j.1525-1497.2004.30423.x