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- Title
A Simple and Versatile Amide Directing Group for C−H Functionalizations.
- Authors
Zhu, Ru-Yi; Farmer, Marcus E.; Chen, Yan-Qiao; Yu, Jin-Quan
- Abstract
Achieving selective C−H activation at a single and strategic site in the presence of multiple C−H bonds can provide a powerful and generally useful retrosynthetic disconnection. In this context, a directing group serves as a compass to guide the transition metal to C−H bonds by using distance and geometry as powerful recognition parameters to distinguish between proximal and distal C−H bonds. However, the installation and removal of directing groups is a practical drawback. To improve the utility of this approach, one can seek solutions in three directions: 1) Simplifying the directing group, 2) using common functional groups or protecting groups as directing groups, and 3) attaching the directing group to substrates via a transient covalent bond to render the directing group catalytic. This Review describes the rational development of an extremely simple and yet broadly applicable directing group for PdII, RhIII, and RuII catalysts, namely the N-methoxy amide (CONHOMe) moiety. Through collective efforts in the community, a wide range of C−H activation transformations using this type of simple directing group have been developed.
- Subjects
CHEMICAL bonds; BOND formation mechanism; CHEMICAL reactions; CHEMICAL processes; ACTIVATORS (Chemistry); TRANSITION metals
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 36, p10578
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201600791