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- Title
Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent Targeting pqs Quorum Sensing.
- Authors
Lu, Cenbin; Maurer, Christine K.; Kirsch, Benjamin; Steinbach, Anke; Hartmann, Rolf W.
- Abstract
The virulence regulator PqsR of Pseudomonas aeruginosa is considered as an attractive target for attenuating the bacterial pathogenicity without eliciting resistance. However, despite efforts and desires, no promising PqsR antagonist has been discovered thus far. Now, a surprising functionality change of a highly affine PqsR antagonist in P. aeruginosa is revealed, which is mediated by a bacterial signal molecule synthase and responsible for low cellular potency. Blockade of the susceptible position led to the discovery of the first antivirulence compound that is potent in vivo and targets PqsR, thus providing a proof of concept for this novel antivirulence therapy.
- Subjects
PSEUDOMONAS aeruginosa; QUINOLONE antibacterial agents; ANTIBACTERIAL agents; ANTIVIRAL agent synthesis; QUORUM sensing
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 4, p1109
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201307547