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- Title
Mother-to-infant transmission of hepatitis C virus.
- Authors
Resti, M; Azzari, C; Lega, L; Rossi, ME; Zammarchi, E; Novembre, E; Vierucci, A; Rossi, M E
- Abstract
Anti-hepatitis C virus (HCV) antibodies and HCV-RNA were measured in the sera of 22 anti-HCV positive, HIV-1 negative mothers and their infants. ELISA and RIBA II were used for anti-HCV determination. HCV-RNA was measured by a nested polymerase chain reaction. HCV-RNA was found in 12 of 22 mothers. All 22 children were followed for 12 months. All were anti-HCV positive by the fourth month; 18 became anti-HCV negative between the 8th and 12th month. HCV-RNA was detected in 5 of 22 infants in the fourth month. They remained HCV-RNA positive. All children born to HCV-RNA negative mothers were HCV-RNA negative while 5 of 12 babies born to HCV-RNA positive mothers were infected. All five infected babies were born to mothers infected through transfusions or drug use. ALT levels in mothers seemed to have no effect on mother-to-infant transmission. Hence evidence for perinatal transmission of HCV from HCV-RNA positive mothers was demonstrated in the present study.
- Publication
Acta Paediatrica, 1995, Vol 84, Issue 3, p251
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/j.1651-2227.1995.tb13624.x