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- Title
Neutrophil-to-Monocyte-Plus-Lymphocyte Ratio as a Potential Marker for Discriminating Pulmonary Tuberculosis from Nontuberculosis Infectious Lung Diseases.
- Authors
Jeon, You La; Lee, Woo-In; Kang, So Young; Kim, Myeong Hee
- Abstract
Objective To determine whether NMLR has more statistical strength than NLR in discriminating TB from non-TB infectious lung diseases. Methods Among patients who underwent 3 or more TB culture tests with molecular study between January 2016 and December 2017, 110 patients with TB, and 159 patients diagnosed with non-TB infectious lung diseases were enrolled. The original complete blood count (CBC) parameters and modified CBC indices, including NLR and NMLR, were analyzed. Results The NLR and NMLR were significantly lower in TB patients than in patients with other infectious lung diseases. However, the area under the curve (AUC) for NMLR (0.90; 95% confidence interval [CI], 0.86–0.93) was significantly greater than that for NLR (0.88 [0.84–0.92]). Conclusions The neutrophil-to-monocyte-plus-lymphocyte ratio (NMLR) can be used as a new index that is more powerful than neutrophil-to-lymphocyte ratio (NLR) in discriminating tuberculosis (TB) from non-TB infectious lung diseases. NMLR had more statistical strength than NLR in discriminating TB from non-TB infectious lung diseases.
- Subjects
BIOMARKERS; BLOOD cell count; CHI-squared test; CONFIDENCE intervals; STATISTICAL correlation; LUNG diseases; LYMPHOCYTES; MONOCYTES; NEUTROPHILS; PNEUMONIA; TUBERCULOSIS; RETROSPECTIVE studies; RECEIVER operating characteristic curves; DATA analysis software; MANN Whitney U Test
- Publication
Laboratory Medicine, 2019, Vol 50, Issue 3, p286
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmy083