We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation of Gastric Fundus Invagination for Weight Loss in a Porcine Model.
- Authors
Darido, Elias; Overby, D.; Brownley, Kim; Farrell, Timothy
- Abstract
Gastric fundus compliance allows stomach volume increase in response to food intake. Absence of this postprandial relaxation alters hormonal signals and induces early satiety and weight loss. This study demonstrates the effect of gastric fundus invagination on the growth rate of juvenile pigs. After institutional animal care and use committee approval, 15 juvenile pigs were divided into two groups. In the first group, six pigs were anesthetized, weighed, and submitted to laparotomy, stomach manipulation, and short gastric vessel ligation. This is the control group and is referred to as 'Sham'. In the second group, gastric fundus invagination was added by using a circular stapler. This is the procedure group and is designated as 'GFI'. Postoperatively, body weight and food intake were measured for 5 weeks. Pigs were euthanized and the stomachs examined. Growth patterns were compared. Three animals were excluded from the analysis. At the end of the 5-week study period, six GFI pigs had intact anastomosis with an invaginated fundus. The mean percent growth rate for the GFI group (54.2 ± 2.8 %) was significantly less than the Sham group (77.7 ± 4.9 %). Gastric fundus invagination significantly decreases the growth rate in juvenile pigs.
- Subjects
GASTRIC fundus; WEIGHT loss; LABORATORY swine; INGESTION; POSTOPERATIVE care; CONTROL groups; ABDOMINAL surgery
- Publication
Obesity Surgery, 2012, Vol 22, Issue 8, p1293
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-012-0666-4