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- Title
Iodoacetamide blank compensation in FXIII functional assays: Is it still necessary?
- Authors
Savard, Philippe; Leguy‐Seguin, Vanessa; Chavy, Camille; Genre‐Volot, Fabienne; Callegarin, Anamaria; Amiral, Jean; Bonnotte, Bernard; Lecompte, Thomas; de Maistre, Emmanuel
- Abstract
The article focuses on the necessity of Iodoacetamide blank compensation in FXIII functional assays, particularly in the context of inherited factor XIII deficiency, a rare bleeding disorder affecting 1 in 2,000,000 people. Topics include the tetrameric structure of plasma FXIII, the role of activated FXIII (FXIIIa) in stabilizing the fibrin network, and the life-threatening bleeding consequences associated with severe inherited FXIII deficiency, emphasizing its impact on coagulation.
- Subjects
HEMORRHAGIC diseases; PROTHROMBIN time; INTRACRANIAL hemorrhage; CATASTROPHIC illness; BLOOD coagulation factors; AMIDES; PHENOTYPES
- Publication
International Journal of Laboratory Hematology, 2023, Vol 45, Issue 6, p969
- ISSN
1751-5521
- Publication type
Article
- DOI
10.1111/ijlh.14111