We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
PEGylation and Zwitterionization: Pros and Cons in the Renal Clearance and Tumor Targeting of Near-IR-Emitting Gold Nanoparticles.
- Authors
Liu, Jinbin; Yu, Mengxiao; Ning, Xuhui; Zhou, Chen; Yang, Shengyang; Zheng, Jie
- Abstract
Got it PEGged: PEGylation and zwitterionization have distinct effects on the pharmacokinetic and tumor‐targeting properties of luminescent gold nanoparticles (AuNPs), although both strategies lead to effective renal clearance. High tumor‐targeting efficiency and specificity were obtained with PEGylated AuNPs, whereas rapid tumor detection was more readily achieved with zwitterionic AuNPs. HD=hydrodynamic diameter, GS=glutathione.
- Subjects
POLYETHYLENE glycol; ZWITTERIONS; IONIZATION (Atomic physics); PERMEABILITY (Biology); RETICULOENDOTHELIAL granulomas; NEAR infrared spectroscopy; GOLD nanoparticle synthesis; THERAPEUTICS
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 48, p12572
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201304465