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- Title
The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children.
- Authors
Albuquerque, David; Nóbrega, Clévio; Manco, Licínio
- Abstract
Aim The -13910C>T single nucleotide polymorphism located upstream of the lactase gene ( LCT) was found tightly associated with lactase persistence in European populations. Recently, it was also associated with body mass index ( BMI) and obesity in European adults. The aim of this study was to test the association of -13910C>T polymorphism with obesity-related traits and risk of obesity in children. Methods We genotyped 580 Portuguese children (6-12-year-olds) for the -13910C>T polymorphism using TaqMan probes by real-time PCR. Anthropometric measurements were assessed in all children. Obesity was defined according to the International Obesity Task Force ( IOTF) cut-offs and abdominal obesity using the sex and age-specific ≥90th waist circumference percentile. Results We found indication for an association between the-13910*T allele and children abdominal obesity (odds ratio [ OR] = 1.41; 95% confidence intervals [ CI]: 1.03-1.94; p = 0.030). Under the dominant model, the indicative association was observed between the LCT-13910 CT/ TT genotypes and abdominal obesity, remaining significant after adjustment for age and gender ( OR = 1.65; 95% CI: 1.04-2.60; p = 0.029). No association was detected with the risk of obesity (p = 0.350). Conclusion Our results suggest that the -13910C>T polymorphism may predispose to abdominal obesity in Portuguese children. The association with BMI or risk of obesity, previously observed in adults, was not confirmed.
- Subjects
CHILDHOOD obesity; SINGLE nucleotide polymorphisms; LACTASE persistence; BODY mass index; PORTUGUESE people; ABDOMEN
- Publication
Acta Paediatrica, 2013, Vol 102, Issue 4, pe153
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1111/apa.12134