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- Title
Phase II study of oral VP-16-213 in small cell lung cancer.
- Authors
Matsui, Yasaku; Oshima, Shunsaku; Kado, Masao; Nakayama, Masahiko; Shimokata, Kaoru; Sakai, Shuzo; Ito, Fumio; Chikata, Eiji; Hara, Kohei; Kanda, Tetsuro; Shima, Kiyoshi; Takenaka, Shinobu; Hokama, Seitetsu; Genga, Keiichiro; Matsui, Y; Oshima, S; Kado, M; Nakayama, M; Shimokata, K; Sakai, S
- Abstract
The soft, gelatin capsule of VP-16-213 (etoposide) was given orally and evaluated in a Phase II study of 56 patients with histologically confirmed small cell lung cancer. The drug was given in a dose of 200 mg/body/day orally for 5 consecutive days, and the courses were repeated every 3 to 4 weeks depending upon the individual patient recovery from myelosuppression. An overall objective response was obtained in 17 patients (30%), five previously treated (23%) and 12 untreated (35%). The median days for response after the start of treatment was 14 d (range, 5 to 64), and the median duration of response was 62 days (range, 28 to 278). The dose-limiting factor was leukopenia, while thrombocytopenia was also experienced. Gastrointestinal reactions to toxicity and alopecia were also observed, but they were not overwhelming. The study demonstrated that the VP-16-213 soft gelatin capsule given orally is effective against small cell lung cancer without clinical cross-resistance to other cytotoxic agents. Its usefulness in combination chemotherapy is thus suggested.
- Subjects
CLINICAL drug trials; ETOPOSIDE; LUNG tumors; ORAL drug administration; SMALL cell carcinoma
- Publication
Cancer (0008543X), 1987, Vol 60, Issue 12, p2882
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19871215)60:12<2882::AID-CNCR2820601205>3.0.CO;2-A