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- Title
The prognostic significance of lymph-vascular space invasion in stage I endometrial cancer.
- Authors
Hanson, Michael B.; van Nagell, John R.; Powell, Deborah E.; Donaldson, Elvis S.; Gallion, Holly; Merhige, Michael; Pavlik, Edward J.; Hanson, M B; van Nagell, J R Jr; Powell, D E; Donaldson, E S; Gallion, H; Merhige, M; Pavlik, E J
- Abstract
Surgical specimens from 111 patients with Stage I endometrial cancer were reviewed for the presence of lymph-vascular space invasion by tumor cells. Lymph-vascular space invasion was noted in 16 cases, and occurred most frequently in poorly differentiated tumors with deep myometrial penetration. Tumor recurrence developed in 44% of patients whose tumors demonstrated lymph-vascular space invasion as opposed to only 2% of patients without this finding (p less than 0.001). Of seven patients with lymph-vascular space invasion who experienced tumor recurrence, five developed extra-pelvic metastases. Discriminant function analysis of these data revealed a statistically significant correlation between lymph-vascular space invasion and tumor recurrence, independent of histologic differentiation of myometrial penetration. These findings suggest that lymph-vascular space invasion by tumor cells is an important prognostic variable in Stage I endometrial cancer which should be considered in treatment planning.
- Publication
Cancer (0008543X), 1985, Vol 55, Issue 8, p1753
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850415)55:8<1753::AID-CNCR2820550823>3.0.CO;2-P