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- Title
Losartan and the United States costs of end-stage renal disease by baseline albuminuria in patients with type 2 diabetes and nephropathy.
- Authors
Alexander, Charles M.; Lyle, Paulette A.; Keane, William F.; Carides, George W.; Zhongxin Zhang; Shahnaz Shahinfar
- Abstract
Losartan and the United States costs of end-stage renal disease by baseline albuminuria in patients with type 2 diabetes and nephropathy.Background.Type 2 diabetes is the leading cause of end-stage renal disease (ESRD). The Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) study provided the opportunity to estimate costs associated with ESRD by baseline albuminuria from a United States perspective.Methods.Costs for ESRD in patients with diabetes were estimated by baseline albuminuria using the U.S. Renal Data System by using the number of days each patient experienced ESRD and the daily estimated U.S. cost of ESRD.Results.The losartan-based antihypertensive therapy group experienced a 28.6% (P= 0.002) reduction in the risk of the development of ESRD compared with placebo-based conventional antihypertensive therapy. The previously estimated annual ESRD-related cost saving in the losartan group was$5,144 (95% CI$1,701–$8,586,P= 0.003) at 3.5 years. With the cost of losartan, the net savings in the losartan group was estimated at$3,522 ($143–$6,900,P= 0.041) by 3.5 years. More ESRD-free days were observed and reduced ESRD costs estimated with losartan-based treatment over all levels of baseline albuminuria.Conclusion.Treatment with losartan in patients with type 2 diabetes and nephropathy in the RENAAL study not only reduces the incidence of ESRD, but is also estimated from a U.S. perspective to result in substantial cost savings over the 3.5-year duration of the trial across all levels of baseline albuminuria.
- Subjects
UNITED States; CHRONIC kidney failure; ANGIOTENSIN-receptor blockers; ALBUMINURIA; TYPE 2 diabetes; KIDNEY diseases
- Publication
Kidney International Supplement, 2004, Issue 92, pS115
- ISSN
0098-6577
- Publication type
Article
- DOI
10.1111/j.1523-1755.2004.09228.x