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- Title
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
- Authors
Yue, Wei-Hua; Wang, Hai-Feng; Sun, Liang-Dan; Tang, Fu-Lei; Liu, Zhong-Hua; Zhang, Hong-Xing; Li, Wen-Qiang; Zhang, Yan-Ling; Zhang, Yang; Ma, Cui-Cui; Du, Bo; Wang, Li-Fang; Ren, Yun-Qing; Yang, Yong-Feng; Hu, Xiao-Feng; Wang, Yi; Deng, Wei; Tan, Li-Wen; Tan, Yun-Long; Chen, Qi
- Abstract
To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, Pcombined = 4.76 × 10?11, odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, Pcombined = 6.91 × 10?12, OR = 0.78; rs2142731 in an intron of PGBD1, Pcombined = 5.14 × 10?10, OR = 0.79) and 11p11.2 (rs11038167 near the 5? UTR of TSPAN18, Pcombined = 1.09 × 10?11, OR = 1.29; rs11038172, Pcombined = 7.21 × 10?10, OR = 1.25; rs835784, Pcombined = 2.73 × 10?11, OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.
- Subjects
CHINA; HUMAN genome; LOCUS (Genetics); INTRONS; LABORATORY mice; GENE expression; CHINESE people
- Publication
Nature Genetics, 2011, Vol 43, Issue 12, p1228
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.979