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- Title
β[sub 2]-Microglobulin/CD8 -/- Mice Reveal Significant Role for CD8[sup +] T Cells in Graft Rejection Responses in β[sub 2]-Microglobulin -/- Mice.
- Authors
Freland; Ljunggren
- Abstract
β[sub 2]-microglobulin (β[sub 2]m) -/- mice have often been used as a model to investigate host resistance to grafted tissues in the absence of CD8[sup +] T cells. However, the realization that β[sub 2]m -/- mice have a small pool of CD8[sup +] T cells imply that these cells may take part in immune responses in vivo. To directly address the role of CD8[sup +] T cell responses in β[sub 2]m -/- mice, we introduced a CD8 null mutation into these mice. The β[sub 2]m/CD8 -/- mice and the corresponding control mice were primed, and challenged with syngeneic tumour grafts. While β[sub 2]m -/- mice readily cleared such tumour grafts, similar tumour grafts grew progressively in a dose dependent manner in the β[sub 2]m/CD8 -/- mice. The present results imply that residual CD8[sup +] T cells in β[sub 2]m -/- mice may carry out significant biological functions, and suggest that studies using β[sub 2]m -/- mice as a model for CD8[sup +] T cell deficiency must be regarded with some caution.
- Subjects
T cells; GRAFT rejection
- Publication
Scandinavian Journal of Immunology, 2000, Vol 51, Issue 3
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.2000.00712.x