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- Title
Tenidap, but not Nonsteroidal Anti-Inflammatory Drugs, Inhibits T-Cell Proliferation and Cytokine Induction.
- Authors
Dolhain, R. J. E. M.; De Kuiper, P.; Verweij, C. L.; Penders, J. M. A.; Breedveld, F. C.; Dijkmans, B. A. C.; Miltenburg, A. M. M.
- Abstract
T-lymphocytes are involved in the inflammatory response that occurs in affected joints of patients with rheumatoid arthritis (RA). Some second-line disease modifying anti-rheumatic drugs used in the treatment of patients with RA are known to block T-cell activation. The present study assessed whether tenidap, an investigational anti-rheumatic drug, affects <em>in vitro</em> T-cell responses such as proliferation and cytokine production. It was found that tenidap, in contrast to several nonsteroidal anti-inflammatory drugs, inhibits anti-CD3 or IL-2 driven proliferative responses of cloned human T-cells. Furthermore, tenidap was found to inhibit IFN-γproduction as well as the induction of mRNA encoding IFN-γ or TNF-α. The results indicate that tenidap may exert at least part of its anti-inflammatory activity via inhibition of T-cell function and cytokine production.
- Subjects
ANTIRHEUMATIC agents; T cells; RHEUMATOID arthritis; INFLAMMATION; ANTI-inflammatory agents; PATIENTS
- Publication
Scandinavian Journal of Immunology, 1995, Vol 42, Issue 6, p686
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1995.tb03712.x