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- Title
Peptide Binding Sites Recognized by Anti-Mucin (MUC2) Monoclonal Antibodies.
- Authors
Xing, P.-X.; Apostolopoulos, V.; Prenzoska, J.; Devine, P. L.; McKenzie, I. F. C.
- Abstract
Multiple genes coding for human mucins have been identified (MUC 1-5) and here monoclonal antibodies (MoAb) to a gastrointestinal mucin-MUC2 are examined. The antibodies were made to a synthetic peptide representing a single repeat in the core protein of the variable number of tandem repeat region. Using the six-mer overlapping peptides synthesized on polyethylene pins, different binding sites were detected by five anti-MUC 2 MoAbs. These contained amino acids: STTT, PTT, GTQTP, TPTP and PTTT (one antibody), and TPTPT. The repeat region of M UC2 essentially is hydrophobic, but contain useful immunogenic sites. This information will be useful for studying the structure and function of MUC2.
- Subjects
MUCINS; PEPTIDES; MONOCLONAL antibodies; GASTROINTESTINAL system; IMMUNOGENETICS; POLYETHYLENE; AMINO acids
- Publication
Scandinavian Journal of Immunology, 1993, Vol 38, Issue 6, p591
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1993.tb03246.x