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- Title
Discrete Association of CD3 and CD4 Molecules in T-Cell Stimulation Acting Through the Autologous Mixed Lymphocyte Reaction and the CD3/T-Cell Receptor Complex in Human Autoreactive T-Cell Clones.
- Authors
Hara, M.; Kitani, A.; Harigai, M.; Suzuki, K.; Hirose, T.; Kawakami, M.; Kawagae, M.; Nakamura, H.
- Abstract
To investigate autologous antigen recognition, we developed two autoreactive CD4+ T-cell clones. A2and A10 maintained with non-T cells and IL-2, Autologous non-T-cell stimulation of the T-cell clones resulted in ii decrease in cell surface expression or CD4, whereas the expression of CD2. CD3. and WT31 was unchanged. Activation of the autoreacttve T-cell clones by cell surface binding anti-CD3 MoAb; is a specific antigen stimulator of the T-cell receptor complex, induced cell surface antigen comodulation of CD3. CD4, and WT31, These data suggest a discrete association of CD3 and CD4 molecules in T-cell stimulation acting through the autologous mixed lymphocyte reaction and the CD3/T-cell receptor complex, PMA treatment resulted in concomitant down-regulation of CD3 and CD4 but calcium ionophore treatment did not. Thus, it appears that phosphorilation of CD3 leads to the down-regulation of surface antigens of CD4.
- Subjects
CELL membranes; CELL receptors; T cells; CD4 antigen; VIRAL receptors; ORGANIC compounds
- Publication
Scandinavian Journal of Immunology, 1991, Vol 33, Issue 2, p141
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb03744.x