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- Title
Effects of Calmodulin Antagonists Cd<sup>2+</sup> and Trifluoperazine on Mixed Lymphocyte Culture Cell-Mediated Lysis and Antibody-Dependent Cell Cytolysis.
- Authors
Wolff, C. H. J.
- Abstract
The effects of two substances with calmodulin-antagonistic properties, cadmium and trifluoperazone, were studied on mixed lymphocyte culture-cell mediated lysis (MLC-CML) and antibody-dependent cell cytolysis (ADCC). Both cadmium and trifluoperazine readily inhibited MLC-CMC, while ADCC was inhibited only to a small extent or not at all, Trifluoperazine almost completely inhibited phagocytosis in cells whose ability to lyse antibody-coated red blood cells was unimpaired. The results suggests a striking difference in the extent in which calmodulin mediated processes take part in MLC-CML on the one hand and ADCC on the other. This indicates a profound dissimilarity in the mechanisms of these two types of cell-mediated lysis.
- Subjects
CALMODULIN; CALCIUM-binding proteins; CADMIUM; IMMUNE response; IMMUNOLOGY; PHAGOCYTOSIS
- Publication
Scandinavian Journal of Immunology, 1986, Vol 23, Issue 6, p663
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1986.tb02002.x