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- Title
Origin of Peripheral Blood Macrophages in Bursa-Cell-Reconstituted Chickens.
- Authors
Vainio, O.; Peck, R.; Koch, C.; Toivanen, A.
- Abstract
MHC class-I antigens on peripheral blood macrophages and bursa cells were analysed after adoptive bursa cell transfer to cyclophosphamide-treated immunodeficient chickens. We studied the expression of B-F locus-encoded antigens (B-F is homologous to mouse H-2K, D) on macrophages and B cells and found that macrophage B-F antigens are of host origin, whereas bursa cells express only donor-type B-F antigens. Both syngeneic and allogeneic bursa cells restored IgM antibody production to a T-cell-independent antigen, Brucella, but only syngeneic bursa cells could restore the IgG antibody response to a thymus-dependent antigen, sheep erythrocytes. The results indicate that B-cell maturation and macrophage-B-cell interaction are not MHC-restricted but that a restriction exists in T-cell-B-cell collaboration.
- Subjects
MHC antibodies; MAJOR histocompatibility complex; ANTIGENS; IMMUNITY; MACROPHAGES; RETICULO-endothelial system; CONNECTIVE tissue cells; ANTIGEN presenting cells; B cells
- Publication
Scandinavian Journal of Immunology, 1983, Vol 17, Issue 2, p193
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1983.tb00782.x