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- Title
Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria.
- Authors
Leonardo, Leo; Kenangalem, Enny; Poespoprodjo, Jeanne R.; Noviyanti, Rintis; Price, Ric N.; Anstey, Nicholas M.; Minigo, Gabriela; Kho, Steven
- Abstract
Background: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria. Methods: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia. Results: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria. Conclusion: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.
- Subjects
NEW Guinea (Island); INDONESIA; MYELOID-derived suppressor cells; MALARIA; PLASMODIUM vivax
- Publication
Malaria Journal, 2022, Vol 21, Issue 1, p1
- ISSN
1475-2875
- Publication type
Article
- DOI
10.1186/s12936-022-04268-6